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In: Heilman KM, Valenstein E (eds) Clinical neuropsychology, vol 5

Pharmacological inhibition of ATM (e.g., KU-55933) reduces mitochondrial transcription factor A (TFAM) expression in melanoma and breast cancer cells, promotes mtDNA leakage into the cytoplasm, activates the cGAS-STING signaling pathway and downstream cytokine production, and enhances lymphocyte infiltration into the TME, resulting in anti-tumor therapeutic effects (80)

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Does conventional anti-bipolar and antidepressant drug therapy reduce NMDA-mediated neuronal excitation by downregulating astrocytic GluK2 function

Then, another enzyme called acetaldehyde dehydrogenase (ALDH) converts acetaldehyde into acetate, which is further broken down into water and carbon dioxide that your body can eliminate

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